What is Vyleesi?

Vyleesi (bremelanotide) is an FDA-approved prescription medication used to treat acquired, generalized Hypoactive Sexual Desire Disorder (HSDD) in premenopausal women. It is administered as a self-injection about 45 minutes before anticipated sexual activity.

How Does It Work?

Vyleesi activates melanocortin receptors in the brain, which are believed to be involved in sexual arousal. This may help boost sexual desire in some women. (Paraphrased from prescribing information and clinical literature)

Who Can Use Vyleesi?

Vyleesi is indicated for premenopausal women who have low sexual desire that causes distress or interpersonal difficulties. It is not for use in men or women with low desire due to medical, psychological, or relationship issues.

How is Vyleesi Taken?

• Self-injected into the thigh or abdomen at least 45 minutes before sex
• Do not use more than one dose in 24 hours
• Limit to 8 doses per month

(This usage guideline comes from FDA labeling)

Benefits of Vyleesi

• On-demand treatment—use only when needed
• Works within about 45 minutes
• Can improve sexual desire in some women with HSDD
• Non-hormonal approach

Side Effects and Warnings

Common side effects include:

• Nausea (most common)
• Flushing or warmth
• Headache
• Injection site reactions
• Temporary increase in blood pressure

⚠️ Important: Vyleesi should not be used by women with uncontrolled high blood pressure or heart disease. Blood pressure should be monitored if used regularly. (Based on FDA warnings)

Who Should Avoid Vyleesi?

• Women with heart or blood pressure problems
• Pregnant or breastfeeding women
• Anyone allergic to bremelanotide

How Effective Is Vyleesi?

In clinical trials, women using Vyleesi reported modest improvements in sexual desire and reduced distress. It doesn’t work for everyone and should be evaluated after 8 weeks. (Paraphrased from trial results and FDA reviews)

Conclusion

Vyleesi is a convenient, as-needed treatment option for women experiencing low sexual desire due to HSDD. It offers a non-hormonal, fast-acting solution—though its benefits, side effects, and proper usage must be carefully discussed with a healthcare provider.

Sources / Scientific References:

• Official Vyleesi Website
• FDA Label for Vyleesi (2019)
• Clayton AH et al. “Bremelanotide for Female HSDD: Randomized Trials.” J Sex Med. 2016.
• NCBI Article on Bremelanotide Efficacy & Safety